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Kate Clair Cruden Hughes, Amy Hai Yan Chan

Asthma affects nearly 300 million people worldwide.1 Despite a notable decline in age-standardized prevalence, mortality and disability-adjusted life years over the past three decades, the burden of asthma remains high in many countries including low-middle-income countries.2 Climate change is also predicted to significantly impact asthma and other respiratory-related conditions, as rising global temperatures lead to longer pollen […]

Wayne Anderson, ATS 2021: Targeting the MARCKS Protein in Respiratory Disease

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Published Online: Jun 2nd 2021

It was a pleasure to meet with Dr Wayne Anderson (UNC School of Medicine, Chapel Hill, NC, US) to discuss his recent study evaluating the safety and tolerability of BIO­‑11006 in patients with acute respiratory distress syndrome.

A Phase II, Placebo‑Controlled, Multicenter Pilot Study to Evaluate the Safety and Efficacy of BIO­‑11006 Inhalation Solution in Patients with Acute Respiratory Distress Syndrome.‘ (ABSTRACT NUMBER: A2668) was presented at ATS 2021 International Conference, 14-19 May, 2021.

Questions

  1. What is the rationale for targeting the MARCKS protein (myristoylated alanine rich protein kinase C substrate) in respiratory disease? (0:16)
  2. Could you tell us a little about BIO-11006, its mechanism of action and the conditions for which it is being investigated? (3:24)

Disclosures: Wayne Anderson has nothing to disclose in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Victoria Jones.

Filmed as a highlight of ATS 2021 (Virtual).

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