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A 68-year-old woman with nodular bronchiectasis presents with persistent productive cough, intermittent regurgitation and recurrent ‘chest infections’ despite 12 months of once-daily proton pump inhibitor (PPI) therapy. Her clinician has doubled the PPI dose and is considering long-term azithromycin. Sputum has not been sent for mycobacterial culture in over a year. She has lost 3 kg, at times […]

Mark L Metersky, CHEST 2018 – Empiric antibiotic therapy: challenges and recommendations

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Published Online: Oct 12th 2018

Mark L Metersky (University of Connecticut School of Medicine, Farmington, CT, US) discusses current recommendations and guidelines with respect to the use of empiric antibiotic therapy in patients with ventilator-associated pneumonia.

Questions

1. What are the major challenges of empiric antibiotic therapy in patients with ventilator-associated pneumonia? (0:10)
2. How are patients defined in terms of risk when selecting antibiotic treatment? (1:49)
3. What are the recommendations of the latest guidelines in the treatment of patients with risk factors for multidrug resistance and high mortality risk? (2:59)
4. What is the current recommended antibiotic treatment duration for high- and low-risk patients? (3:25)
5. What are the limitations of the current guidelines? (6:03)

Speaker disclosure: Mark L Metersky has nothing to disclose in relation to this video interview.

Filmed at the CHEST Annual Meeting, San Antonio, TX, US, October 2018.

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