ERS Highlights

Altitude can exacerbate chronic obstructive pulmonary disease (COPD symptoms) and has associated adverse health effects. We are joined by Dr Michael Furian (University of Zurich, Zurich, Switzerland) to explore the adverse health effects and significant influence on patient quality of life, and current management strategies. We also take a closer look at two pivotal trials, […]

CLEAN-PCD is a phase 2 randomized, double-blind, placebo-controlled crossover trial investigating the efficacy and safety of idrevloride in primary ciliary dyskinesia (PCD). It was a pleasure to talk with Dr. Thomas Ferkol (UNC Department of Pediatrics, Chapel Hill, NC, USA) around the mechanism of action of idrevloride, the methodology of the CLEAN-PCD study, and the […]

Varenicline was approved as a replacement therapy for smoking back in 2007 in Australia, the uptake for varenicline has remained high despite issues associated with patient adherence and access to the therapy. In this interview, touchRESPIRATORY were delighted to speak with Prof. Michael Abramson (Monash University, Victoria, Australia) to discuss his randomized, placebo-controlled trial evaluating […]

COUGH 1 and COUGH 2, were randomized, double-blind, placebo-controlled phase 3 trials, that investigated gefapixant for the treatment of refractory or unexplained chronic cough. It was a pleasure to speak with Dr. Imran Satia (McMaster University, Hamilton, ON, Canada) around his analysis of COUGH-1 and -2, looking at gefapixant efficacy by patient history of refractory […]

With limited options in the treatment paradigm for refractory or unexplained chronic cough, P2X3 receptor antagonists have shown great promise in clinical trials. We were delighted to speak to Dr. Imran Satia (McMaster University, Hamilton, ON, Canada) to discuss the current unmet needs when treating chronic cough and the investigational P2X3 receptor antagonists currently in […]

Gefapixant is a P2X3 antagonist that was recently studied in two phase 3 randomized controlled trials, COUGH-1 and COUGH-2, and is currently under regulatory review in Europe. In this interview, we were delighted to speak with Elena Kum (McMaster University, Hamilton, ON, Canada) around the aims, methodology and findings from her dose-response meta-analysis of gefapixant. […]

The InPedILD trial was a phase 3, double-blind placebo-controlled trial investigating nintedanib in children and adolescents with fibrosing interstitial lung diseases (ClinicalTrials.gov: NCT04093024). We were delighted to speak to Dr. Robin Deterding (University of Colorado; Children’s Hospital Colorado, Aurora, CO, USA) to discuss the aims, design, eligibility criteria and findings from the phase 3 study. […]

Nintedanib is an inhibitor of tyrosine kinases involved in the progression of pulmonary fibrosis and blocks the signalling pathways involved in fibrotic processes. We were delighted to speak to Dr. Robin Deterding (University of Colorado; Children’s Hospital Colorado, Aurora, CO, USA) around the incidence, prognosis and unmet needs in the treatment of childhood interstitial lung […]

TRAIL1 (ClinicalTrials.gov Identifier: NCT02808871) was a phase 2 randomised, double blind, placebo-controlled trial investigating pirfenidone in rheumatoid arthritis-associated interstitial lung disease (RA-ILD). We were delighted to speak to Professor Ivan O. Rosas (Baylor College of Medicine, Baylor Medicine McNair Campus, Houston, TX, USA) around the aims, design and inclusion criteria of the TRAIL1 study and […]