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A 68-year-old woman with nodular bronchiectasis presents with persistent productive cough, intermittent regurgitation and recurrent ‘chest infections’ despite 12 months of once-daily proton pump inhibitor (PPI) therapy. Her clinician has doubled the PPI dose and is considering long-term azithromycin. Sputum has not been sent for mycobacterial culture in over a year. She has lost 3 kg, at times […]

James Wingfield Digby, ERS 2022: Low-dose Opiates for Refractory/Unexplained Chronic Cough

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Published Online: Sep 15th 2022

Chronic cough is a persistent cough lasting ≥8 weeks and is estimated to affect between 2-18% of the global population. touchRESPIRATORY were delighted to speak with Dr. James Wingfield Digby (University of Manchester, Manchester, UK) around the aims and design of the real world study investigating low-dose opiates in the treatment of chronic cough and the findings in terms of verbal severity score and tolerability.

The abstract ‘Real World Effectiveness and Tolerability of low-dose opiates for Refractory/Unexplained Chronic Cough (RCC/UCC) in a tertiary clinic.’ was presented at ERS 2022, 4–6 September, 2022.

Questions

  1. What is known about the effectiveness of low-dose opiates for refractory/unexplained chronic cough? (0:24)
  2. What were the aims and design of your real world study? (1:46)
  3. What were the study findings in terms of verbal severity score? (2:42)
  4. What were the tolerability findings? (4:31)
  5. What future studies are planned? (5:40)

Disclosures: James Wingfield Digby has nothing to disclose in relation to this video interview.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones.

Filmed in coverage of the ERS meeting 2022.

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