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Kate Clair Cruden Hughes, Amy Hai Yan Chan

Asthma affects nearly 300 million people worldwide.1 Despite a notable decline in age-standardized prevalence, mortality and disability-adjusted life years over the past three decades, the burden of asthma remains high in many countries including low-middle-income countries.2 Climate change is also predicted to significantly impact asthma and other respiratory-related conditions, as rising global temperatures lead to longer pollen […]

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Approximately half of all smokers will develop chronic obstructive pulmonary disease (COPD), with a disease progression over several years before the spirometric threshold for diagnosis is reached.1 There is, therefore, a clear benefit in identifying patients with COPD as early ...

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The nasal airway serves as the primary entry point of air and oxygen into the body. It serves critical functions, such as providing a physical barrier against external irritants and pathogens and warming and humidifying incoming air.1 Consequently, disorders of ...

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Sleep disordered breathing in children comprises a spectrum of abnormal breathing patterns associated with increased airflow resistance and sleep disruption. Sleep disordered breathing is categorized by severity into primary snoring, upper airway resistance syndrome, and obstructive sleep apnea (OSA). Pediatric ...

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Subcutaneous emphysema (SE) is relatively common in the intensive care unit (ICU) and often a complication of positive pressure ventilation.1,2 While typically self-limiting and benign, life-threatening sequela can develop. Progressive accumulation of subcutaneous air can result in significant compressive forces ...

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Respiratory syncytial virus (RSV) is an RNA virus that causes lung and respiratory tract infections. It is a leading cause of morbidity and mortality, and is the second largest cause of death in children under 1 year of age. In 2017, it ...

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Breathing problems during sleep commonly occur in children. Obstructive sleep apnoea (OSA) is the most common breathing-related problem that occurs during sleep and snoring is the main symptom. Habitual snoring, which is defined as snoring for more than three days ...

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Pulmonary arterial hypertension (PAH) is a rare, deadly and incurable condition.1 With a five-year survival rate below 60%, the outcome of this disease is not any better than that of many cancers.1,2 However, numerous treatment options are currently available: more than 20 ...

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Adaptive servo-ventilation (ASV) is a non-invasive ventilatory therapy that provides variable inspiratory positive airway pressure (IPAP) to support inspiration when breathing amplitude is reduced, ensures sufficient respiration when respiratory effort is absent and provides fixed or variable end-expiratory PAP (EPAP) ...

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