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Showing Results for acute exacerbations in chronic obstructive pulmonary disease
Asthma affects nearly 300 million people worldwide.1Â Despite a notable decline in age-standardized prevalence, mortality and disability-adjusted life years over the past three decades, the burden of asthma remains high in many countries including low-middle-income countries.2Â Climate change is also predicted ...
The European Commission has approved dupilumab (Regeneron and Sanofi)) as an add-on maintenance treatment for adults with uncontrolled chronic obstructive pulmonary disease (COPD) characterized by raised blood eosinophils.
Welcome to the latest edition of touchREVIEWS in Respiratory & Pulmonary Diseases. As we continually strive to deliver cutting-edge research and insightful commentary, this issue is no exception, featuring a diverse array of articles that illuminate both emerging treatments and ...
Approximately half of all smokers will develop chronic obstructive pulmonary disease (COPD), with a disease progression over several years before the spirometric threshold for diagnosis is reached.1 There is, therefore, a clear benefit in identifying patients with COPD as early ...
Interstitial lung diseases (ILDs) are a heterogeneous group of disorders characterized by inflammation and/or fibrosis.1Â Pulmonary fibrosis develops due to repeated cycles of injury and impaired repair with fibroblast activation and migration with the resultant deposition of extracellular matrix ...
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are the dominant cause of the worsening and high mortality of chronic obstructive pulmonary disease (COPD), and are associated with higher healthcare costs as part of COPD management. AECOPD is characterized by ...
The topic of the carbon footprint of human activities is one frequently discussed worldwide. There have been conscious efforts across multiple fields, including healthcare, to reduce their carbon footprint. In Canada, 4.6% of greenhouse gases (GHG) are manufactured by the healthcare ...
Dupilumab is an investigational monoclonal antibody that mitigates type 2 inflammation by blocking IL-4 and IL-13 receptors in patients with COPD. We were delighted to talk with Prof. Klaus F. Rabe (University of Kiel, Germany) around the unmet needs in the ...
The definition of chronic obstructive pulmonary disease (COPD) has recently been reformulated better to encompass the heterogeneous nature of this lung condition.1Â The new definition is broader, includes risk factors other than smoking, and aims to improve the diagnosis, management ...
There is a genuine interest on the part of researchers and the pharmaceutical industry in developing so-called ‘bifunctional’ drugs – that is, single molecules with two different primary pharmacological actions.1,2 In this context, single molecules that are capable of simultaneously inducing ...
Asthma and chronic obstructive pulmonary disease (COPD) are disorders with predominantly chronic inflammatory airway features. They are increasingly recognized as entities on a heterogeneous obstructive airway disease continuum with distinct phenotypes, various degrees of overlap, and the predominance of asthma ...
The lack of well-validated biomarkers for monitoring disease activity, predicting future clinical outcomes and the effect of therapeutic interventions highlights the need to find new biomarkers in chronic obstructive pulmonary disease (COPD). In recent years, extensive research has gone into ...
Asthma, classically defined as a chronic inflammatory disease of the lower respiratory tract, is a heterogeneous array of clinical disorders that differ in intensity, occurrence, triggers, comorbidities, genetics, clinical course and prognosis.1Â It manifests as wheezing, cough, dyspnoea, chest tightness ...
Obesity hypoventilation syndrome (OHS) is defined as daytime hypercapnia (awake resting PaCO2 of ≥45 mmHg) in the setting of obesity (body mass index [BMI] ≥30 kg/m2). Most, if not all, patients have some sleep disordered breathing in the form of obstructive ...
As our ability to treat and manage chronic medical conditions improves, we will see a greater number of our patients manifesting physiologic as well as pathologic changes associated with aging. The objective of this article is to provide a brief ...
Strategy reports from both the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 20201 and the Global Initiative for Asthma (GINA) 20192 highlight the importance of using the triple combination of inhaled corticosteroids (ICS), long-acting β2-agonists (LABAs), and long-acting muscarinic receptor antagonists (...
A new coronavirus (SARS-CoV-2) infection began to disseminate in Wuhan, China in early December 2019 and has rapidly spread to almost every country around the globe, with the number of confirmed cases increasing every day. The disease condition associated with this ...
Acute respiratory tract infections (RTIs) affect children and adults with chronic respiratory conditions throughout the world, and are associated with significant morbidity and mortality.1 Acute RTIs are one of the leading causes of mortality in both children and adults, with ...
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