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A 68-year-old woman with nodular bronchiectasis presents with persistent productive cough, intermittent regurgitation and recurrent ‘chest infections’ despite 12 months of once-daily proton pump inhibitor (PPI) therapy. Her clinician has doubled the PPI dose and is considering long-term azithromycin. Sputum has not been sent for mycobacterial culture in over a year. She has lost 3 kg, at times […]

James R Klinger, CHEST 2018 – Management of pulmonary arterial hypertension

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Published Online: Oct 12th 2018

James R Klinger (Rhode Island Hospital, and Warren Alpert Medical School, Brown University, Providence, RI, US) chats to us on the topic of his session entitled: Current Quandaries in Pulmonary Arterial Hypertension (PAH) Management.

Questions

1. What are the major challenges in the management of pulmonary arterial hypertension (PAH)? (0:10)
2. What have been the most important recent developments in PAH therapy? (0:44)
3. What are the pros and cons of front line combination therapy versus sequential therapy? (1:22)
4. What is the role of oral anticoagulation therapy in the management of PAH? (2:17)
5. What are the major gaps in our knowledge of PAH management that require addressing? (2:53)

Speaker disclosure: James R Klinger’s institution receives grant support from Actelion, Bayer, Eiger BioPharmaceuticals, Lung International and United Therapeutics.

Filmed at the CHEST Annual Meeting, San Antonio, TX, US, October 2018.

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